{"Procedure":"<ol>     <li style=\"margin-bottom: 0cm;line-height: 100%;text-align: left;background: transparent;margin-top: 0.49cm;\">Turn on the OptoMotor system and start the patient data management</li>     <li style=\"margin-bottom: 0cm;line-height: 100%;text-align: left;background: transparent;\">Place the mouse on the central stage in the drum</li>     <li style=\"margin-bottom: 0cm;line-height: 100%;text-align: left;background: transparent;\">Select the visual acuity testing conditions: contrast 99,72% and rotation speed 12 &deg;/s, and start the trial.</li>     <li style=\"margin-bottom: 0.49cm;line-height: 100%;text-align: left;background: transparent;\">Once the staircase testing is reaching the final spatial frequency threshold value save the measurement and result.</li> </ol>","Purpose":"<p>\r\n\tTo detect abnormalities in eye morphology.</p>\r\n","Experimental Design":"<div class=\"expandable\">\n\t<ul>\n\t\t<li>\n\t\t\t<strong>Minimum number of animals :</strong>&nbsp; 7M + 7F</li>\n\t\t<li>\n\t\t\t<strong>Age at test: </strong>Week 60 </li>\n\t\t<li>\n\t\t\t<strong>Sex:</strong> We do not expect the results of this test to show sexual dimorphism</li>\n\t</ul>\n</div>\n<p>\n\t&nbsp;</p>\n","Notes":"<ul>\n\t<li>\n\t\tAs a minimum, all abnormalities should be imaged.\n\t\t<ul style=\"list-style-type:circle;\">\n\t\t\t<li>\n\t\t\t\tWhere capacity permits, all mice can be imaged</li>\n\t\t</ul>\n\t</li>\n</ul>\n<ul>\n\t<li>\n\t\tMajority of parameters can be analysed using the standard approach for assessing categorical data. To increase power for analysis purposes, where an abnormality is detected in the left, right or both eyes, the data may be combined to generate one &quot;abnormal&quot; category.</li>\n</ul>\n<p>\n\t<strong>Data QC</strong></p>\n<p>\n\tImage QC is typically performed during data collection to ensure high quality images are captured whilst eyes are dilated etc.</p>\n"}