{"Procedure":"<ol>\r\n<li>The respective mouse is identified via the ear tag.</li>\r\n<li>Mouse skin is analyzed in a non-invasive manner with a special Tewameter (AquaFluxAF200) that is placed on the skin. During a short time of 60 to 90 seconds, TEWL [g/(m2h)] is recorded.</li>\r\n</ol>","Purpose":"Indicator of the skin's barrier function. Transepidermal Water Loss is defined as the measurement of the quantity of water that passes from inside a body through the epidermal layer (skin) to the surrounding atmosphere via diffusion and evaporation processes. Measurements of TEWL are useful for identifying skin damage caused by pathological conditions such as eczema, certain chemicals, or physical insult, as rates of TEWL increase in proportion to the level of damage.","Experimental Design":"<ul>\r\n<li><strong>Minimum number of animals :</strong> &nbsp;7M +7F</li>\r\n<li><strong>Age at test: </strong>Week 73</li>\r\n<li><strong>Sex:</strong> We do not expect the results of this test to show sexual dimorphism.</li>\r\n</ul>","Notes":"The measurement should be performed in the abdominal region until the measurement curve remains stable (max. 90 seconds)."}