{"Purpose":"

To perform histopathological examination and annotation of the IMPC’s standard list of organs (see IMPReSS Gross Pathology & Tissue Collection) on stained tissue sections oriented on glass slides (see IMPReSS Tissue Embedding & Block Banking).

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Significance Score

Not significant. Interpreted by the histopathologist to be a finding attributable to background strain (e.g. low-incidence hydrocephalus, microphthalmia) or incidental to mutant phenotype (e.g. hair-induced glossitis, focal hyperplasia, mild mononuclear cell infiltrate).

OR

Significant. Interpreted by the histopathologist as a finding not attributable to background strain and not incidental to mutant phenotype.


Severity Score

Score

Term

Definition

0

Normal

No lesion(s) or abnormalities detectable considering the age and sex of the animal

1

Mild

Abnormality visible, involving single or multiple tissue types in a minimal proportion of an organ, likely to have no functional consequence

2

Moderate

Abnormality visible, involving multiple tissue types in a minority proportion of an organ, likely to have no clinical consequence (subclinical)

3

Marked

Abnormality clearly visible, involving multiple tissue types in a majority proportion of an organ, likely to have minor clinical manifestation(s)

4

Severe

Abnormality clearly visible, involving multiple tissue types in almost all visible area of an organ, likely to have major clinical manifestation(s)


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